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ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — what worked for you? Page 3

Adiponectin and leptin changes on GLP-1 therapy — what worked for you?

bri_stats Mon, Dec 15, 2025 at 5:59 AM 39 replies 1,546 viewsPage 3 of 8
kate.chem
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Dec 15, 2025 at 10:22 PM#11
Dr.SleepRoch said:
BethLabQueen said: ...mental health should only be used alongside therapy...

One year anniversary on mental health — reflections:

What I wish I'd known: the side effects are temporary, the benefits compound over time, protein is more important than I thought, and the mental health aspect needs as much attention as the physical.

What surprised me: how much my relationship with food changed, the cascade of health improvements beyond weight, and how supportive this community is.

What I'd do differently: start therapy earlier, prioritize resistance training from day 1, and stop comparing my progress to others. Everyone's journey is unique.

22 20steve_okc, dave_SLC, FDA_TrackerJim and 19 others
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cory_ATX
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Austin, TX
Dec 16, 2025 at 3:18 AM#12
Dr.LeslieOBGYN said:
Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming…

This is exactly what I could not find anywhere else. Sending this to two other people who asked me the same thing last week.

Last edited: Dec 16, 2025 at 5:18 AM
23 21andrew_nyc, Dr.EndoEP, GraceAZ_72 and 20 others
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MikeKY_noInsulin
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Oct 2024
Louisville, KY
Dec 16, 2025 at 8:14 AM#13
Dr.SleepRoch said:
BethLabQueen said: ...mental health should only be used alongside therapy...

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
Last edited: Dec 16, 2025 at 11:14 AM
24 22Dr.SportsMedIN, amy_econ_NJ, bbq_ray_KC and 21 others
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labquiet_amy
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Mar 2024
Cambridge, MA
Dec 16, 2025 at 1:10 PM#14
bri_stats said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

25 23bri_stats, pete_manc_UK, anna.melb_AU and 22 others
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Admin
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Dec 16, 2025 at 6:06 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.

Last edited: Dec 16, 2025 at 10:06 PM
26 24PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 23 others
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