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ForumsPharmacology & MechanismsGLP-1R desensitization — 12 month update Page 3

GLP-1R desensitization — 12 month update

WendyG_ATL Sat, Aug 16, 2025 at 8:18 AM 40 replies 1,750 viewsPage 3 of 8
PharmacoVig_BOS
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Aug 17, 2025 at 5:31 PM#11
hans_munich said:
I want to add the drug interaction perspective on the pharmacology.

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

35 8amsterdam_pete, LondonLisa, mike_nyc and 32 others
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roxy_nash
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Aug 17, 2025 at 8:30 PM#12
Dr.SportsMedIN said:
The mechanism is more central than most summaries suggest.

Bookmarking. The distinction being drawn above is the one nobody else makes. Sending this to two other people who asked me the same thing last week.

36 9roxy_nash, tony_orlando, Dr.NephBHM_UK and 33 others
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anders_CPH
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Aug 17, 2025 at 11:29 PM#13
hans_munich said:
I want to add the drug interaction perspective on the pharmacology.

This is where I part company with the consensus forming above. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

I would rather be corrected than agreed with, if it comes to it.

37 10AussieAnna, BethLabQueen, ChrisMacros and 34 others
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VendorMark
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Aug 18, 2025 at 2:28 AM#14

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

38 11Dr.PeteFamMed, claudia_zurich, nancy_portland and 35 others
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mike_mod
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Aug 18, 2025 at 5:27 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Report rather than reply if it drifts again.

39 12PurityPaulOR, MaxMetOK, MounjBrad and 36 others
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