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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsReceptor internalization and recycling — anyone have experience? Page 4

Receptor internalization and recycling — anyone have experience?

jennifer_SEA Sat, Apr 26, 2025 at 6:12 AM 36 replies 2,034 viewsPage 4 of 8
Dr.ObesityLA
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Apr 28, 2025 at 7:26 AM#16

From the other side of the consultation, briefly. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

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FDA_TrackerJim
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Apr 28, 2025 at 2:49 PM#17

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Apr 28, 2025 at 5:49 PM
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FitDadDave
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Apr 28, 2025 at 10:12 PM#18

One thing that is still open after NicoleRaleigh’s answer:

What would you measure differently if you were starting again?

Last edited: Apr 29, 2025 at 1:12 AM
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newstart_MO
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Apr 29, 2025 at 5:35 AM#19
FDA_TrackerJim said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

Correct me if the detail matters more than I have assumed.

Last edited: Apr 29, 2025 at 11:35 AM
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mike_mod
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Apr 29, 2025 at 12:58 PM#20

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Thread quality here is what the rules are for. Keep it up.

Last edited: Apr 29, 2025 at 2:58 PM
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