🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsReceptor internalization and recycling — anyone have experience? Page 6

Receptor internalization and recycling — anyone have experience?

jennifer_SEA Sat, Apr 26, 2025 at 6:12 AM 36 replies 2,034 viewsPage 6 of 8
pat_auckland
Member
345
1,567
Jun 2024
Auckland, NZ
May 5, 2025 at 4:57 AM#26

One thing that is still open after sophie_paris’s answer:

What did you change at the same time, and can you separate the two now?

Last edited: May 5, 2025 at 8:57 AM
42 15NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 39 others
Reply Quote Save Share Report
Dr.GutHealth
Senior Member
1,456
7,890
Mar 2024
Minnesota
May 6, 2025 at 6:39 AM#27
kate.chem said:
Say what you would expect to see if you were wrong, before you look.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

43 16tyler_CSCS, VanRx_Mike, steve_okc and 40 others
Reply Quote Save Share Report
raj_cambridge
Member
489
2,123
Jun 2024
Cambridge, MA
May 7, 2025 at 8:20 AM#28
kate.chem said:
Say what you would expect to see if you were wrong, before you look.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

Ask again with the specifics and you will get a better answer than this one.

Last edited: May 7, 2025 at 9:20 AM
44 17TomTeleRx, DoseLogDan, SleepFixSam and 41 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
Dr.CardioMD
VIP Member
2,678
14,567
Dec 2023
Cleveland, OH
May 8, 2025 at 10:01 AM#29
kate.chem said:
Say what you would expect to see if you were wrong, before you look.

Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.

45 18roxy_nash, tony_orlando, Dr.NephBHM_UK and 42 others
Reply Quote Save Share Report
jennifer_SEA
Member
234
890
Nov 2024
Seattle, WA
May 9, 2025 at 11:41 AM#30

OP back with an update, since a thread like this is useless without one.

Closing this out: the trough rather than the peak explains the pattern I was seeing on day six, which I had been blaming on the vial.

17 15hyun_seoul, jim_asheville, matt_MKE and 14 others
Reply Quote Save Share Report

Similar Threads

GLP-1R desensitization — β-arrestin-mediated internalization18 replies
Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance13 replies
Semaglutide albumin binding and the C-18 fatty acid linker17 replies
GIP receptor pharmacology — why GIP agonism enhances GLP-113 replies
Glucagon receptor signaling — hepatic glycogenolysis and lipolysis16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register