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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesGot off metformin for the first time in 8 years - crying happy tears — need advice Page 3

Got off metformin for the first time in 8 years - crying happy tears — need advice

gary_naperville Wed, Sep 10, 2025 at 9:24 PM 29 replies 1,622 viewsPage 3 of 6
MikeNYC_runner
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Sep 14, 2025 at 3:42 PM#11
Dr.MetabolicMD said:
Glycemic variability as the key metric for glycaemic control success: my coefficient of variation (CV) on CGM dropped from 41% to 19%.

Bookmarking. The distinction being drawn above is the one nobody else makes. Sending this to two other people who asked me the same thing last week.

18 16PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 15 others
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Dr.PeteFamMed
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Sep 15, 2025 at 9:26 PM#12

From the other side of the consultation, briefly. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

19 17tommy_boulder, hyun_seoul, jim_asheville and 16 others
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Dr.KarenChen
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Sep 17, 2025 at 3:11 AM#13
LindaRN_retired said:
Insulin sensitivity test (HOMA-IR) on glycaemic control — arguably the most important metabolic marker most people aren't tracking: HOMA-IR = (fasting…

This is where I part company with the consensus forming above. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

20 18TomFromTexas, mike.trainer_LA, sarah_nash92 and 17 others
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SleepDoc_PDX
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Sep 18, 2025 at 8:56 AM#14

Adding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

21 19sophie_paris, mel_PDX, Dr.AddMedPHL and 18 others
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mike_mod
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Sep 19, 2025 at 2:42 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.

22 20PurityPaulOR, MaxMetOK, MounjBrad and 19 others
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