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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsSo the drug literally changes your brain?? That is wild — anyone have experience? Page 10

So the drug literally changes your brain?? That is wild — anyone have experience?

Dr.PulmRoch Fri, Jan 31, 2025 at 1:55 PM 49 replies 2,218 viewsPage 10 of 10
carlos_SATX
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Jul 23, 2025 at 4:06 PM#46
PedsEndoPhilly said:
Worth answering the question that was asked rather than the one behind it.

Coming at PedsEndoPhilly’s question from a different direction. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

30 3james_edin, FranDenver, Dr.BariatricHTX and 27 others
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Dr.PulmRoch
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Jul 29, 2025 at 7:33 PM#47

Reporting back.

Update, and it is the boring outcome: nothing was wrong. The measurement I was reading had moved less than its own week-to-week variation, which somebody said upthread and I did not believe.

Last edited: Jul 29, 2025 at 8:33 PM
31 4traveltech_sara, AttorneyGrant, DebRD_ATL and 28 others
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traveltech_sara
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Aug 4, 2025 at 10:57 PM#48

One thing that is still open after PedsEndoPhilly’s answer:

How would you tell the difference between that and the alternative explanation?

Last edited: Aug 5, 2025 at 1:57 AM
32 5wanda_boise, NurseAsh_DET, BenResearch_OR and 29 others
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NeuroNate
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Aug 11, 2025 at 2:17 AM#49
Dr.PulmRoch said:
Update, and it is the boring outcome: nothing was wrong.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

Last edited: Aug 11, 2025 at 8:17 AM
33 6kim_atl_prep, sarah_TO, wendy_avl and 30 others
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PeptideChemSF
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Aug 17, 2025 at 5:34 AM#50
Dr.PulmRoch said:
Update, and it is the boring outcome: nothing was wrong.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

5 3BrianDallas92, labquiet_amy, emily_PDX and 2 others
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