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ForumsPharmacology & MechanismsSo the drug literally changes your brain?? That is wild — anyone have experience? Page 4

So the drug literally changes your brain?? That is wild — anyone have experience?

Dr.PulmRoch Fri, Jan 31, 2025 at 1:55 PM 49 replies 2,218 viewsPage 4 of 10
Dr.AddMedPHL
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Feb 10, 2025 at 8:33 AM#16

Clinical perspective, offered as context rather than as advice. Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third retelling.

37 10FitDadDave, RunnerRach, TrialNerd_Beth and 34 others
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lucas_SP_BR
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São Paulo, BR
Feb 11, 2025 at 8:19 PM#17
Dr.AddMedPHL said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

38 11Dr.ObesityLA, NurseKim_ATL, paul_denver and 35 others
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mike_mod
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Feb 13, 2025 at 8:04 AM#18
Dr.AddMedPHL said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.

Last edited: Feb 13, 2025 at 10:04 AM
39 12DoseLogDan, SleepFixSam, PurityPaulOR and 36 others
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andrew_nyc
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Feb 14, 2025 at 7:48 PM#19
Dr.AddMedPHL said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

40 13julia.endo, JessicaM_2024, TomFromTexas and 37 others
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Dr.PeteFamMed
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Feb 16, 2025 at 7:31 AM#20

Moderator note: a couple of off-topic posts removed.

12 10FranDenver, Dr.BariatricHTX, LindaRN_retired and 9 others
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