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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 6

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 6 of 11
GraceAZ_72
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Tucson, AZ
Mar 29, 2025 at 7:52 AM#26
DanielChem_CHI said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

Last edited: Mar 29, 2025 at 11:52 AM
37 10MariaRD, AussieAnna, BethLabQueen and 34 others
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PharmHunterJen
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Illinois
Apr 11, 2025 at 6:13 PM#27
DanielChem_CHI said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Agreed on the substance. I would put less weight on the timescale, because two months of anything is not enough to distinguish a trend from a wobble.

38 11alex_tucson, kevin_tulsa, Dr.PainCLE and 35 others
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VanRx_Mike
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Vancouver, CA
Apr 25, 2025 at 4:26 AM#28
DanielChem_CHI said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

This answered a question I did not know how to ask. Taking it to my next appointment.

39 12Admin, Dr.Martinez, mike_mod and 36 others
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Dr.ReproEndo
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May 8, 2025 at 2:32 PM#29

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: May 8, 2025 at 3:32 PM
40 13GraceAZ_72, carl_compliance, DanielChem_CHI and 37 others
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pam_columbus
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Columbus, OH
May 22, 2025 at 12:30 AM#30

OP back with an update, since a thread like this is useless without one.

Update — tachyphylaxis to the gastric effect, persistence of the appetite effect. Two curves, and I had been watching the wrong one.

12 10emma_london, tammy_FL, Dr.LipidDallas and 9 others
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