🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsBiased agonism at GLP-1R — 12 month update Page 7

Biased agonism at GLP-1R — 12 month update

pam_columbus Tue, Dec 17, 2024 at 6:06 AM 52 replies 2,746 viewsPage 7 of 11
CryptoCarl
Member
789
3,456
May 2024
Arizona
Jun 4, 2025 at 7:38 AM#31
Dr.ReproEndo said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

There is a second half to this that has not been said yet. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

Correct me if the detail matters more than I have assumed.

Last edited: Jun 4, 2025 at 11:38 AM
13 11CryptoCarl, MariaRD, AussieAnna and 10 others
Reply Quote Save Share Report
NicoleRaleigh
Member
356
1,567
Aug 2024
Raleigh, NC
Jun 17, 2025 at 2:38 PM#32

The figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

14 12MikeFit_NJ, InsuranceTom, WendyG_ATL and 11 others
Reply Quote Save Share Report
bri_stats
Member
789
3,456
May 2024
Seattle, WA
Jun 30, 2025 at 9:30 PM#33

Following on from Dr.ReproEndo — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

Last edited: Jul 1, 2025 at 1:30 AM
15 13TomFromTexas, mike.trainer_LA, sarah_nash92 and 12 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
emily_PDX
Member
245
1,123
Nov 2024
Portland, OR
Jul 14, 2025 at 4:14 AM#34
NicoleRaleigh said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Pushing back on NicoleRaleigh here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

16 14Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 13 others
Reply Quote Save Share Report
EndoResFellow
Member
456
2,345
Sep 2024
Baltimore, MD
Jul 27, 2025 at 10:51 AM#35
NicoleRaleigh said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

Last edited: Jul 27, 2025 at 12:51 PM
17 15Dr.ObesityLA, NurseKim_ATL, paul_denver and 14 others
Reply Quote Save Share Report
15678911

Similar Threads

GLP-1R desensitization — β-arrestin-mediated internalization18 replies
Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance13 replies
Semaglutide albumin binding and the C-18 fatty acid linker17 replies
GIP receptor pharmacology — why GIP agonism enhances GLP-113 replies
Glucagon receptor signaling — hepatic glycogenolysis and lipolysis16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register