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ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 10

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 10 of 10
steph_laguna
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Jul 31, 2024 at 8:17 AM#46
rachel_ABQ said:
Most of what circulates confidently in this community traces back to one summary of one study, and the qualifier was dropped somewhere in the third…

Mine went the same way, slower. The detail I would add is minor and it is already implied above.

9 7Dr.EndoEP, GraceAZ_72, carl_compliance and 6 others
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SkepticalSean
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Jul 31, 2024 at 3:34 PM#47

OP back with an update, since a thread like this is useless without one.

Closing the loop. The answer turned out to depend on the detail I had left out of the opening post, which is a lesson about how to ask rather than about the subject.

10 8paige_pharma, emma_london, tammy_FL and 7 others
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RunnerRach
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Jul 31, 2024 at 10:50 PM#48

Old thread, but it comes up first when you search for this, so it is worth updating. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

Ask again with the specifics and you will get a better answer than this one.

Last edited: Aug 1, 2024 at 1:50 AM
11 9Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 8 others
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MaxMetOK
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Aug 1, 2024 at 6:06 AM#49

Following on from rachel_ABQ — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

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DanielChem_CHI
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Aug 1, 2024 at 1:22 PM#50
RunnerRach said:
If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

Correct me if the detail matters more than I have assumed.

34 7nick_SD_fit, ben_calgary, patPC_UT and 31 others
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