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ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 8

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 8 of 10
fiona_VT
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Jul 28, 2024 at 7:06 AM#36
Dr.AddMedPHL said:
If you are going to change something, change one thing and give it long enough to express itself.

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

Last edited: Jul 28, 2024 at 8:06 AM
28 1mark_tokyo, hans_munich, jason_sac26 and 25 others
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TinaHashiRN
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Jul 28, 2024 at 2:28 PM#37

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

29 2mike_mod, SarahChen_PharmD, sarah.morrison and 26 others
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hannah_MT
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Jul 28, 2024 at 9:50 PM#38
TinaHashiRN said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Adding a me-too, because a thread of one person's experience is not much use. Posting only so the count is not one.

30 3MaxMetOK, MounjBrad, nick_newbie and 27 others
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SteveThurs
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Jul 29, 2024 at 5:12 AM#39
TinaHashiRN said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Coming at TinaHashiRN’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

31 4DoseLogDan, SleepFixSam, PurityPaulOR and 28 others
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DanielChem_CHI
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Jul 29, 2024 at 12:34 PM#40

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

3 1nick_SD_fit, ben_calgary, patPC_UT
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