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ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 5

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 5 of 10
PeptideChemSF
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Jul 23, 2024 at 3:41 PM#21

Clinical perspective, offered as context rather than as advice. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Last edited: Jul 23, 2024 at 7:41 PM
42 15steve_okc, dave_SLC, FDA_TrackerJim and 39 others
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pete_RVA
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Jul 23, 2024 at 11:09 PM#22
PeptideChemSF said:
Start from the measurement rather than the conclusion.

This is my experience too, for whatever a second data point is worth. Nothing to add that would improve it.

43 16Dr.Martinez, mike_mod, SarahChen_PharmD and 40 others
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JenPlateau
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Jul 24, 2024 at 6:37 AM#23
PeptideChemSF said:
Start from the measurement rather than the conclusion.

There is a second half to this that has not been said yet. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

44 17RunnerRach, TrialNerd_Beth, HPLC_Greg and 41 others
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Dr.PathRoch
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Jul 24, 2024 at 2:05 PM#24

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Last edited: Jul 24, 2024 at 8:05 PM
45 18SaraMom3, Dr.MetabolicMD, RetaRick_CA and 42 others
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Dr.SportsMedIN
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Jul 24, 2024 at 9:33 PM#25

Following on from PeptideChemSF — and this may be the naive question:

Was that from a primary source or from a summary of one?

46 19rachel_ABQ, traveltech_sara, AttorneyGrant and 43 others
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