DoseLogDan said:

Practical: whatever you change, write down the date and the reason.

This answered a question I did not know how to ask.

Adding the clinical framing, because it changes how the question reads. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Ask again with the specifics and you will get a better answer than this one.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.

ingrid_STO said:

The mechanism and the magnitude are separate questions.

Coming at ingrid_STO’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

The figures, for anyone assembling their own picture. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.