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ForumsOral GLP-1 AgonistsATTAIN-2: orforglipron in T2DM — 12 month update Page 5

ATTAIN-2: orforglipron in T2DM — 12 month update

RetaRick_CA Sat, Aug 16, 2025 at 1:22 PM 35 replies 1,535 viewsPage 5 of 7
Dr.SurgeonPGH
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Aug 25, 2025 at 5:32 AM#21

A narrower follow-up, since the general answer is now clear:

How would you tell the difference between that and the alternative explanation?

4 4DoseLogDan, SleepFixSam, PurityPaulOR and 1 other
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MariaRD
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Jun 2024
New Mexico
Aug 26, 2025 at 9:02 AM#22
Dr.CardioMD said:
Start from the measurement rather than the conclusion.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

That is the short version; the long version is somebody else's post.

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MaxMetOK
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Dec 2024
Oklahoma
Aug 27, 2025 at 12:31 PM#23
Dr.CardioMD said:
Start from the measurement rather than the conclusion.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

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Dr.SportsMedIN
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Indianapolis, IN
Aug 28, 2025 at 4:00 PM#24
Dr.CardioMD said:
Start from the measurement rather than the conclusion.

Thank you for spelling out the reasoning rather than just the conclusion. Sending this to two other people who asked me the same thing last week.

1 1Dr.SurgeonPGH
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Dr.Martinez
Medical Advisor
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Boston, MA
Online
Aug 29, 2025 at 7:28 PM#25

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

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