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ForumsOral GLP-1 AgonistsATTAIN-2: orforglipron in T2DM — 12 month update Page 6

ATTAIN-2: orforglipron in T2DM — 12 month update

RetaRick_CA Sat, Aug 16, 2025 at 1:22 PM 35 replies 1,535 viewsPage 6 of 7
denise_HTX
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Aug 30, 2025 at 10:55 PM#26
Dr.Martinez said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

This is my experience too, for whatever a second data point is worth. The detail I would add is minor and it is already implied above.

Last edited: Aug 31, 2025 at 12:55 AM
49 24sarah.morrison, NeuroNate, JessicaH_TX and 46 others
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JenPlateau
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Sep 1, 2025 at 2:22 AM#27
Dr.Martinez said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Adding the part of the answer the thread has not reached. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

Correct me if the detail matters more than I have assumed.

48 23TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 45 others
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anders_CPH
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Sep 2, 2025 at 5:48 AM#28

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Worth separating that from glycaemic control, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

47 22AussieAnna, BethLabQueen, ChrisMacros and 44 others
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emma_london
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Sep 3, 2025 at 9:13 AM#29

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

46 21JessicaM_2024, TomFromTexas, mike.trainer_LA and 43 others
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RetaRick_CA
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Sep 4, 2025 at 12:38 PM#30

OP back with an update, since a thread like this is useless without one.

Resolved, and the thing that resolved it was the least interesting suggestion in the thread. Writing that down for the next person who wants the interesting answer.

24 24MounjBrad, nick_newbie, DadBodDave and 21 others
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