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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — leucine threshold discussion Page 3

Muscle protein synthesis rates on GLP-1 — leucine threshold discussion

ChrisMacros Mon, May 25, 2026 at 8:37 AM 21 replies 460 viewsPage 3 of 5
PurityPaulOR
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May 26, 2026 at 12:35 AM#11
GenomicsKate said:
The honest range is roughly 20 to 40% of total loss as lean mass without deliberate resistance training, and roughly 10 to 20% with it plus adequate…

Right, and protein targets should be set on a reference weight rather than current weight. Setting 1.6 g/kg on a starting weight of 130kg produces a target nobody hits on a suppressed appetite.

42 15Dr.LeslieOBGYN, MikeNYC_runner and 39 others
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paige_pharma
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May 26, 2026 at 11:20 AM#12
robert_kc said:
True, and anyone with reduced kidney function needs that target set by a clinician rather than a forum.

This is exactly what I could not find anywhere else. I will report back once I have actually tried it.

Last edited: May 26, 2026 at 12:20 PM
43 16Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 40 others
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DebRD_ATL
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May 26, 2026 at 10:05 PM#13
GenomicsKate said:
The honest range is roughly 20 to 40% of total loss as lean mass without deliberate resistance training, and roughly 10 to 20% with it plus adequate…

This is where I part company with the consensus forming above. I think this board over-worries about lean mass. Some lean loss is obligatory — you need less muscle to move a smaller body, and preserving mass you no longer need is not a health outcome. The question is whether strength and function held, and mine did.

44 17SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 41 others
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Dr.PeteFamMed
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May 27, 2026 at 8:50 AM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

45 18Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 42 others
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Admin
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May 27, 2026 at 7:35 PM#15

Moderator note: a couple of off-topic posts removed. Carry on.

46 19PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 43 others
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