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ForumsOral GLP-1 AgonistsHow far away are we really from an oral option — 12 month update Page 10

How far away are we really from an oral option — 12 month update

HPLC_Greg Wed, Jun 4, 2025 at 7:45 PM 47 replies 2,552 viewsPage 10 of 10
PedsEndoPhilly
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Jun 20, 2025 at 1:22 AM#46

Following on from Dr.CardioMD — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

20 18sarah_TO, wendy_avl, jason_paloalto and 17 others
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HPLC_Greg
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Jun 20, 2025 at 1:47 PM#47

Reporting back.

I moved the tablet to the moment I wake up rather than trying to fit it around breakfast, and the difference in the following weeks was obvious. It was a timing problem, not a dose problem.

21 19JenPlateau, SallyK_inj, CryptoCarl and 18 others
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AmyNC_wife
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Jun 21, 2025 at 2:12 AM#48
VendorMark said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

Ask again with the specifics and you will get a better answer than this one.

22 20PharmD_Rodriguez, julia.endo, JessicaM_2024 and 19 others
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SarahChen_PharmD
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Jun 21, 2025 at 2:37 PM#49
VendorMark said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Bookmarking. The distinction being drawn above is the one nobody else makes.

23 21TinaHashiRN, robert_kc, dan_philly and 20 others
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CarlaRPh_TPA
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Jun 22, 2025 at 3:01 AM#50

Clinical perspective, offered as context rather than as advice. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

Correct me if the detail matters more than I have assumed.

45 18emily_PDX, Dr.SleepRoch, laura_annarbor and 42 others
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