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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsOrforglipron and hepatic first-pass metabolism — anyone have experience? Page 6

Orforglipron and hepatic first-pass metabolism — anyone have experience?

Dr.EM_Chicago Fri, Jan 31, 2025 at 6:59 PM 44 replies 1,967 viewsPage 6 of 9
steph_laguna
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Feb 14, 2025 at 6:46 AM#26
SleepDoc_PDX said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

29 2Dr.EndoEP, GraceAZ_72, carl_compliance and 26 others
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Dr.CardioMD
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Feb 15, 2025 at 5:59 PM#27

Adding the clinical framing, because it changes how the question reads. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

30 3Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 27 others
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mike_mod
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Feb 17, 2025 at 5:12 AM#28
Dr.CardioMD said:
It is worth asking what the claim would look like if it were false.

Second this. Nothing to add that would improve it.

Last edited: Feb 17, 2025 at 7:12 AM
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ingrid_STO
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Feb 18, 2025 at 4:24 PM#29
Dr.CardioMD said:
It is worth asking what the claim would look like if it were false.

Coming at Dr.CardioMD’s question from a different direction. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

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Dr.EM_Chicago
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Feb 20, 2025 at 3:35 AM#30

Reporting back.

Late follow-up. I did not do what was suggested, I did something adjacent, and it worked; posting the difference in case it matters to somebody.

Last edited: Feb 20, 2025 at 7:35 AM
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