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ForumsPsychological & BehavioralTherapy is just as important as the medication - my experience — November 2025

Therapy is just as important as the medication - my experience — November 2025

rick_sfbay Tue, Nov 4, 2025 at 10:14 AM 9 replies 1,217 viewsPage 1 of 2
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rick_sfbay
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Nov 4, 2025 at 10:14 AM#1

A reference post rather than a discussion. Corrections are the point; I would rather this be right than mine. It is about mood and mental health, and it is deliberately narrow — everything I am not confident about is marked as such.

What is actually established

The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously. On the positive side: reduced anxiety around food, better self-image, more confidence. On the difficult side: grief for the years lost, identity disruption, relationships built around eating, and the loss of food as a coping mechanism with nothing put in its place. Rarer but real: anhedonia and emotional flatness. Regulators have started asking for validated patient-reported outcomes in this class; the existing data gap is not evidence of absence.

The condition it depends on

For anyone with an eating-disorder history this needs a clinician in the loop rather than a forum. The same drug can be therapeutic in binge-eating disorder and actively harmful in a restrictive disorder.

What I am not sure about

What would genuinely help is knowing how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot. Happy to be told the question itself is wrong.

— rick_sfbay · corrections welcome and will be edited into this post with credit
12 7mike_mealprep, NicoleRaleigh, james_edin and 9 others
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LabKate
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Nov 4, 2025 at 10:29 AM#2
rick_sfbay said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.
rick_sfbay said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

Last edited: Nov 4, 2025 at 1:29 PM
11 6laura_annarbor, JenMemphis, pat_auckland and 8 others
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FDA_TrackerJim
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Nov 4, 2025 at 10:44 AM#3
rick_sfbay said:
The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

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hyun_seoul
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Nov 4, 2025 at 10:59 AM#4
FDA_TrackerJim said:
I would be careful about how confidently the flatness reports get attributed.

Body image adjustment with mental health: I've lost 64 lbs but when I look in the mirror, I still see my old self sometimes. "Phantom fat" is a real phenomenon.

My therapist specializes in body image issues with weight loss patients. She says it can take 12-18 months for your brain's body map to update. In the meantime: take progress photos (your eyes lie but cameras don't), try on old clothes, and be patient with yourself.

Last edited: Nov 4, 2025 at 2:59 PM
9 4BariatricNurseD, MASHdoc_SA, GenomicsKate and 6 others
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lisa_labSD
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Nov 4, 2025 at 12:19 PM#5
LabKate said:
rick_sfbay said: ...mental health should only be used alongside therapy...

Adding a me-too, because a thread of one person's experience is not much use.

8 3cory_ATX, lori_vegas, Dr.PulmRoch and 5 others
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