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ForumsOral GLP-1 AgonistsOral semaglutide 50mg (Rybelsus HD) — 12 month update Page 8

Oral semaglutide 50mg (Rybelsus HD) — 12 month update

LibrarianMeg Thu, May 30, 2024 at 6:09 AM 44 replies 2,300 viewsPage 8 of 9
pam_stl
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Jul 25, 2024 at 9:09 PM#36
Dr.NateNeph said:
If you are going to change something, change one thing and give it long enough to express itself.

Thank you for spelling out the reasoning rather than just the conclusion. Adding it to my notes with a link back to this thread.

42 17Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 39 others
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jim_asheville
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Jul 29, 2024 at 1:54 AM#37

From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

41 16BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 38 others
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DataDave
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Aug 1, 2024 at 6:41 AM#38
jim_asheville said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Second this. Nothing to add that would improve it.

40 15LondonLisa, mike_nyc, VendorMark and 37 others
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FranDenver
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Aug 4, 2024 at 11:30 AM#39
jim_asheville said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Coming at jim_asheville’s question from a different direction. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.

Happy to go further on any of that.

Last edited: Aug 4, 2024 at 5:30 PM
39 14MASHdoc_SA, GenomicsKate, Dr.ObesityMed and 36 others
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jason_paloalto
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Aug 7, 2024 at 4:21 PM#40

One concrete data point for the thread. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Correct me if the detail matters more than I have assumed.

Last edited: Aug 7, 2024 at 9:21 PM
17 17Dr.EndoEP, GraceAZ_72, carl_compliance and 14 others
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