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ForumsPublic SquareNovo Nordisk CagriSema Phase 3 results — need advice Page 3

Novo Nordisk CagriSema Phase 3 results — need advice

mike_mod Tue, Nov 18, 2025 at 8:31 PM 43 replies 1,982 viewsPage 3 of 9
LarryQC_SD
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Nov 19, 2025 at 8:40 AM#11
PedsEndoPhilly said:
Read four things before the headline number.

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

Last edited: Nov 19, 2025 at 9:40 AM
5 5NurseKim_ATL, paul_denver, TinaHashiRN and 2 others
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pete_nash
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Nov 19, 2025 at 2:52 PM#12
ingrid_STO said:
Agreed, and subgroup analyses deserve particular suspicion.

Thank you for spelling out the reasoning rather than just the conclusion. Sending this to two other people who asked me the same thing last week.

4 4Dr.Martinez, mike_mod, SarahChen_PharmD and 1 other
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PeptideSynthNJ
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Nov 19, 2025 at 9:04 PM#13
PedsEndoPhilly said:
Read four things before the headline number.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I would add the less popular caveat: these trial populations under-represented several groups, older adults and the highest BMI categories among them. The results probably generalise, and "probably" should be stated as an assumption rather than dropped.

3 3BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio
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Dr.PeteFamMed
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Nov 20, 2025 at 3:17 AM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

2 2Dr.BariatricHTX, LindaRN_retired
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Admin
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Nov 20, 2025 at 9:30 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

1 1PeptideSynthNJ
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