Dr.RenalNash said:

I'm 67 years old and want to share my perspective on cardiovascular risk as an older member of this community.

Adding a me-too, because a thread of one person's experience is not much use.

stefan_berlin said:

Dr.CardioMD said: ...we don't know the long-term effects of cardiovascular risk...

Senior perspective on cardiovascular risk: I'm 64 years old and started this journey skeptically. My cardiologist recommended it after years of failed interventions.

14 months later: down 37 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.

To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.

One concrete data point for the thread. Worth knowing that the injection site changes very little. Abdomen, thigh and upper arm are bioequivalent for semaglutide, so a site change is not a plausible explanation for a bad week.

One thing that is still open after stefan_berlin’s answer:

How much of the between-person variation is pharmacokinetic and how much is just adherence measured badly?

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Carry on.