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ForumsTirzepatide (Mounjaro / Zepbound)SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025 Page 6

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — November 2025

LabKate Sat, Mar 14, 2026 at 9:46 PM 36 replies 1,552 viewsPage 6 of 8
newstart_MO
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Feb 2026
Springfield, MO
Mar 30, 2026 at 3:33 AM#26

One thing that is still open after SarahChen_PharmD’s answer:

Whether anyone has held at a sub-maximal dose long term and kept the result, or whether the maintenance data only exists at 2.4mg?

42 15bri_stats, pete_manc_UK, anna.melb_AU and 39 others
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amy_econ_NJ
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May 2024
Princeton, NJ
Apr 1, 2026 at 12:42 AM#27
josh_phd_bmore said:
Worth knowing that the injection site changes very little.

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

43 16hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 40 others
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Dr.NephBHM_UK
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Birmingham, UK
Apr 2, 2026 at 9:50 PM#28
josh_phd_bmore said:
Worth knowing that the injection site changes very little.

That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.

Correct me if the detail matters more than I have assumed.

Last edited: Apr 3, 2026 at 3:50 AM
44 17PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 41 others
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ben_calgary
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Oct 2024
Calgary, CA
Apr 4, 2026 at 6:57 PM#29
josh_phd_bmore said:
Worth knowing that the injection site changes very little.

Genuinely useful, thank you. I had the facts and not the framework.

45 18JakeSmashed95, NauseaFreeNow, SteveThurs and 42 others
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LabKate
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Jan 2024
Oregon
Apr 6, 2026 at 4:03 PM#30

Closing the loop on my own question.

Update since I posted: I held at 1.7mg for a further twelve weeks and lost another 4kg slowly, which settles it for me. I was escalating because the number was available, not because I had stopped responding.

17 15labquiet_amy, emily_PDX, Dr.SleepRoch and 14 others
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