Dr.PulmRoch said:

Mendelian randomization evidence supporting GLP-1 pathway modulation for cardiovascular risk: genetic variants in the GLP1R gene region associated…

I'm 48 years old and want to share my perspective on cardiovascular risk as an older member of this community.

My doctor was initially hesitant because of my age, but the SELECT trial included patients up to 72 and showed consistent benefit across age groups. We started at the lowest dose with closer monitoring.

15 months later: down 52 lbs, off atorvastatin, A1C from 8.4% to 5.5%. My cardiologist is thrilled. cardiovascular risk is absolutely relevant for older adults — don't let anyone tell you otherwise.

Dr.PulmRoch said:

Mendelian randomization evidence supporting GLP-1 pathway modulation for cardiovascular risk: genetic variants in the GLP1R gene region associated…

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.

From the other side of the consultation, briefly.

6 month update on cardiovascular risk: down 44 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.

Dr.NutriCornell said:

6 month update on cardiovascular risk: down 44 lbs, off blood pressure meds, A1C normalized.

Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.

Dr.NutriCornell said:

6 month update on cardiovascular risk: down 44 lbs, off blood pressure meds, A1C normalized.

Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off losartan entirely! My cardiologist is thrilled.

If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.