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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareIs there a ceiling effect for GLP-1-mediated weight loss? — looking for input Page 3

Is there a ceiling effect for GLP-1-mediated weight loss? — looking for input

VanRx_Mike Sun, Aug 4, 2024 at 4:23 PM 17 replies 2,124 viewsPage 3 of 4
PurityPaulOR
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Aug 8, 2024 at 10:02 PM#11
sarah_TO said:
Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

Right, and the exception is worth naming rather than left implied, because the exception is where people get into trouble.

Last edited: Aug 9, 2024 at 1:02 AM
33 8Dr.LeslieOBGYN, MikeNYC_runner and 30 others
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rachel_ABQ
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Aug 9, 2024 at 9:10 PM#12
SleepFixSam said:
Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational…

That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.

Last edited: Aug 10, 2024 at 2:10 AM
32 7DadBodDave, AmyNC_wife, SkepticalSean and 29 others
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denise_HTX
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Aug 10, 2024 at 8:17 PM#13
sarah_TO said:
Bayesian meta-analysis perspective on the trial evidence: traditional frequentist meta-analyses report point estimates and confidence intervals.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

31 6JessicaH_TX, KevinCompounds, TirzTom and 28 others
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NicoleRaleigh
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Aug 11, 2024 at 7:24 PM#14

Adding the numbers, since they settle part of this. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

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Admin
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Aug 12, 2024 at 6:30 PM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Thread quality here is what the rules are for. Keep it up.

29 4PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 26 others
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