🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersHormone panel changes — testosterone, estradiol on GLP-1 Page 3

Hormone panel changes — testosterone, estradiol on GLP-1

EndoResFellow Sat, Jun 6, 2026 at 10:49 AM 16 replies 308 viewsPage 3 of 4
fiona_glasgow
Member
312
1,345
Aug 2024
Glasgow, UK
Jun 7, 2026 at 6:41 PM#11
SarahChen_PharmD said:
The single most useful discipline is bringing the whole panel to a clinician rather than one flagged value.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

31 6TrialTracker_MD, JennaRN, LabKate and 28 others
Reply Quote Save Share Report
andrew_nyc
Member
534
2,345
Apr 2024
New York, NY
Jun 7, 2026 at 9:21 PM#12

Adding the clinical framing, because it changes how the question reads.

Hormone panel changes on the hormone panel — relevant for anyone curious about endocrine effects:

  • Testosterone: increased 35% (weight loss reduces aromatase in adipose tissue)
  • Estradiol: normalized from elevated baseline
  • SHBG: increased appropriately
  • Free testosterone: increased 22%
  • Cortisol AM: within normal limits, no significant change

My reproductive endocrinologist says the testosterone improvement alone could explain the energy and mood benefits I've experienced.

30 5Dr.NateNeph, PharmD_Rodriguez, julia.endo and 27 others
Reply Quote Save Share Report
PharmD_Rodriguez
Senior Member
3,456
14,567
Jan 2024
Miami, FL
Jun 8, 2026 at 12:02 AM#13
Dr.MetabolicMD said:
Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c…

Sex hormone labs after weight loss on the hormone panel — for the men in this thread:

Testosterone: 357 → 597 ng/dL (dramatic improvement!)
Free T: 7.2 → 13.7 ng/dL
Estradiol: 44 → 27 pg/mL
SHBG: 23 → 43 nmol/L

Visceral fat contains aromatase which converts testosterone to estrogen. As you lose visceral fat, this conversion decreases and testosterone naturally rises. I feel 10 years younger.

29 4robert_kc, dan_philly, MeganSA_TX and 26 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
Dr.PeteFamMed
Senior Member
2,012
9,234
Jan 2024
Minneapolis, MN
Jun 8, 2026 at 2:43 AM#14
EndoResFellow said:
Most of the hormonal change here is a consequence of adiposity falling rather than a drug effect.

HPA axis assessment on the hormone panel: rarely ordered but informative for understanding the stress-metabolism connection:

4-point salivary cortisol:

  • Morning: 17 ng/mL → 12 ng/mL (improved)
  • Noon: 7 ng/mL → 5 ng/mL
  • Evening: 4 ng/mL → 2 ng/mL
  • Night: 2 ng/mL → 1 ng/mL

The cortisol curve is normalizing — less flat, better diurnal variation. Reduced visceral fat = reduced cortisol overproduction. The metabolic benefits cascade into stress hormone regulation.

28 3Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 25 others
Reply Quote Save Share Report
mike_mod
Moderator
7,234
19,823
Nov 2023
New York
Online
Jun 8, 2026 at 5:24 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

27 2PurityPaulOR, MaxMetOK, MounjBrad and 24 others
Reply Quote Save Share Report

Similar Threads

Optimal lab testing frequency on GLP-1 — evidence-based schedule5 replies
A1C from 7.2 to 5.1 — my bloodwork transformation19 replies
Thyroid function monitoring on GLP-1 — TSH and free T4 trends3 replies
Lipid panel improvements mega-thread — share your numbers19 replies
Liver enzymes trending down on GLP-1 — ALT/AST normalization17 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register