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ForumsTirzepatide (Mounjaro / Zepbound)Tirz made me a completely different person holy cow — looking for input Page 3

Tirz made me a completely different person holy cow — looking for input

roxy_nash Wed, Sep 10, 2025 at 7:43 PM 35 replies 1,765 viewsPage 3 of 7
traveltech_sara
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Sep 11, 2025 at 2:53 AM#11
sean_dublin said:
Steady state is faster than people expect: half-life about five days, so you are at plateau in roughly three to four weeks rather than five.

Saving this. It is the first explanation that did not require me to already understand it.

Last edited: Sep 11, 2025 at 5:53 AM
9 9MeganSA_TX, LarryQC_SD, wanda_boise and 6 others
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PedsEndoPhilly
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Sep 11, 2025 at 5:35 AM#12

Adding the clinical framing, because it changes how the question reads. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

8 8wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 5 others
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RetaRick_CA
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Sep 11, 2025 at 8:17 AM#13
Dr.Martinez said:
It is worth asking what the claim would look like if it were false.

Pushing back on Dr.Martinez here. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

7 7DadBodDave, AmyNC_wife, SkepticalSean and 4 others
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dave_SLC
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Sep 11, 2025 at 10:59 AM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Last edited: Sep 11, 2025 at 2:59 PM
6 6FranDenver, Dr.BariatricHTX, LindaRN_retired and 3 others
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Admin
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Sep 11, 2025 at 1:41 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again.

5 5PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 2 others
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