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Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Tirz made me a completely different person holy cow — looking for input Page 6

Tirz made me a completely different person holy cow — looking for input

roxy_nash Wed, Sep 10, 2025 at 7:43 PM 35 replies 1,765 viewsPage 6 of 7
Dr.NephBHM_UK
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Sep 14, 2025 at 12:33 AM#26
Dr.EM_Chicago said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Can confirm. Same sequence, different timescale. I had assumed I was the exception until I read this.

23 23Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 20 others
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MikeFit_NJ
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Sep 14, 2025 at 9:05 AM#27
Dr.EM_Chicago said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Adding the part of the answer the thread has not reached. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Happy to go further on any of that.

22 22marcus_mpls, DeniseRN_TPA, SandraNC_45 and 19 others
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dave_SLC
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Sep 14, 2025 at 5:37 PM#28

The figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

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AussieAnna
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Sep 15, 2025 at 2:09 AM#29

A narrower follow-up, since the general answer is now clear:

How long did you give it before you decided it was working?

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roxy_nash
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Sep 15, 2025 at 10:42 AM#30

Closing the loop on my own question.

Coming back a few months on. It held. Nothing dramatic to report, which is the report.

Last edited: Sep 15, 2025 at 4:42 PM
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