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ForumsCompounding & FormulationCompounded sema potency testing — 6 month update Page 3

Compounded sema potency testing — 6 month update

fiona_glasgow Tue, Sep 24, 2024 at 7:33 AM 14 replies 1,904 viewsPage 3 of 3
HPLC_Greg
Senior Member
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8,901
Feb 2024
Research Triangle, NC
Sep 24, 2024 at 7:08 PM#11
carl_compliance said:
Regarding compounded supply compounding legality: compounding pharmacies can legally produce semaglutide and tirzepatide while these drugs remain on…

Compounding pharmacy customer here with experience relevant to compounded supply.

I've ordered from 4 different compounding pharmacies over the past 14 months. The quality variation is real — purity ranged from 94% to 101% of label claim based on independent Janoshik testing.

My current compounder (a 503B facility) has been consistently 98-101% purity across 8 orders. I pay $123/month vs $1,313 for brand. The savings are substantial and the product is equivalent in my experience.

Re: compounded supply — this applies whether you're using brand or compounded. The clinical principles are the same.

Last edited: Sep 25, 2024 at 1:08 AM
25 0SallyK_inj, CryptoCarl, MariaRD and 22 others
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dan_philly
Member
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Jul 2024
Philadelphia, PA
Sep 24, 2024 at 10:47 PM#12
robert_kc said:
Worth adding the genuine exception, because it is real and narrow: a change made for an identified patient where the prescriber determines it produces…

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

Last edited: Sep 25, 2024 at 1:47 AM
24 24AmyNC_wife, SkepticalSean, Dr.CardioMD and 21 others
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JenMemphis
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Jan 2025
Memphis, TN
Sep 25, 2024 at 2:26 AM#13
carl_compliance said:
Regarding compounded supply compounding legality: compounding pharmacies can legally produce semaglutide and tirzepatide while these drugs remain on…

Vendor communication red flags for compounded supply:

  • Won't provide COA before purchase — walk away
  • Claims "100% pure" without analytical data — unrealistic
  • No physical address or phone number — accountability matters
  • Pushes you to buy more than you need — pressure tactics
  • Won't answer questions about their compounding process — transparency is key
  • Payment only via crypto or wire transfer — legitimate pharmacies accept cards

A legitimate compounding pharmacy operates like a healthcare business, not a gray market dealer.

23 23NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 20 others
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labquiet_amy
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Mar 2024
Cambridge, MA
Sep 25, 2024 at 6:05 AM#14
fiona_glasgow said:
Two pharmacies quoted me last year, one describing itself as 503A and one as 503B, and I assumed 503B just meant bigger until both stopped within…

Compounded has been just as effective for me. If compounded supply is the concern, the COA from my 503B pharmacy shows 99.1% purity. Verified by Janoshik.

22 22bri_stats, pete_manc_UK, anna.melb_AU and 19 others
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mike_mod
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New York
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Sep 25, 2024 at 9:45 AM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Report rather than reply if it drifts again.

21 21PurityPaulOR, MaxMetOK, MounjBrad and 18 others
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