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ForumsRetatrutide & Triple AgonistsTRIUMPH program trial design overview — all Phase 3 arms Page 16

TRIUMPH program trial design overview — all Phase 3 arms

TrialTracker_MD Mon, Feb 26, 2024 at 4:00 PM 324 replies 45,778 viewsPage 16 of 20
sean_dublin
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Sep 20, 2024 at 8:18 PM#76

From the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

41 16hannah_MT, Dr.SportsMedIN, amy_econ_NJ and 38 others
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MariaRD
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Sep 24, 2024 at 6:47 AM#77
sean_dublin said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

This is my experience too, for whatever a second data point is worth.

Last edited: Sep 24, 2024 at 7:47 AM
40 15anders_CPH, Dr.NutriCornell, pam_stl and 37 others
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SarahChen_PharmD
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Sep 27, 2024 at 5:14 PM#78
sean_dublin said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Coming at sean_dublin’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Correct me if the detail matters more than I have assumed.

39 14paul_denver, TinaHashiRN, robert_kc and 36 others
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quinn_sf
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Oct 1, 2024 at 3:39 AM#79

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

38 13andrew_nyc, Dr.EndoEP, GraceAZ_72 and 35 others
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PharmHunterJen
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Oct 4, 2024 at 2:02 PM#80

Following on from sean_dublin — and this may be the naive question:

Was that from a primary source or from a summary of one?

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