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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesMy dad had a heart attack and now I am terrified - will GLP-1 help? — looking for input Page 4

My dad had a heart attack and now I am terrified - will GLP-1 help? — looking for input

PharmHunterJen Thu, Jul 3, 2025 at 12:34 AM 37 replies 2,232 viewsPage 4 of 8
patPC_UT
Member
212
890
Nov 2024
Park City, UT
Jul 6, 2025 at 2:40 AM#16
sean_dublin said:
I want to bring up the cardiovascular angle on cardiovascular risk.

Adding a me-too, because a thread of one person's experience is not much use. I had assumed I was the exception until I read this.

41 16sarah_nash92, FitDadDave, RunnerRach and 38 others
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Dr.PathRoch
Member
456
2,123
Jun 2024
Rochester, MN
Jul 6, 2025 at 12:23 PM#17
Dr.GutHealth said:
Anti-inflammatory mechanisms of GLP-1 agonists and cardiovascular risk: beyond weight loss, GLP-1R activation directly suppresses NF-κB signaling,…

Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my key markers:

Weight: consistent downtrend, -1.5 lbs/week average
Fasting glucose (finger stick): stable at 84 mg/dL
Blood pressure (home): 115/74 average
Resting heart rate: 64 bpm (down from 80)
Waist circumference: down 14 inches total

The resting heart rate improvement correlates with cardiovascular fitness gains. Everything is moving in the right direction.

40 15InsuranceTom, WendyG_ATL, SaraMom3 and 37 others
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TrialNerd_Beth
Senior Member
2,345
11,234
Jan 2024
Bethesda, MD
Jul 6, 2025 at 10:06 PM#18

Following on from Dr.GutHealth — and this may be the naive question:

How long did you give it before you decided it was working?

39 14TomTeleRx, DoseLogDan, SleepFixSam and 36 others
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DanielChem_CHI
Senior Member
1,234
5,678
Mar 2024
Chicago, IL
Jul 7, 2025 at 7:49 AM#19
Dr.PathRoch said:
Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my…

I'm 55 years old and want to share my perspective on cardiovascular risk as an older member of this community.

My doctor was initially hesitant because of my age, but the SELECT trial included patients up to 72 and showed consistent benefit across age groups. We started at the lowest dose with closer monitoring.

8 months later: down 35 lbs, off lisinopril, A1C from 7.0% to 5.2%. My cardiologist is thrilled. cardiovascular risk is absolutely relevant for older adults — don't let anyone tell you otherwise.

Last edited: Jul 7, 2025 at 9:49 AM
38 13ben_calgary, patPC_UT, Dr.DermMIA and 35 others
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mike_mod
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Nov 2023
New York
Online
Jul 7, 2025 at 5:32 PM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Carry on.

16 16PurityPaulOR, MaxMetOK, MounjBrad and 13 others
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