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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesMy dad had a heart attack and now I am terrified - will GLP-1 help? — looking for input Page 7

My dad had a heart attack and now I am terrified - will GLP-1 help? — looking for input

PharmHunterJen Thu, Jul 3, 2025 at 12:34 AM 37 replies 2,232 viewsPage 7 of 8
hank_denver
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Sep 2024
Denver, CO
Jul 22, 2025 at 5:04 PM#31
PharmHunterJen said:
Cardiac biomarkers and cardiovascular risk: my cardiologist ordered advanced cardiac labs given my family history.

Same pattern here, and in the same order.

Last edited: Jul 22, 2025 at 9:04 PM
34 9ingrid_STO, pete_nash, hank_denver and 31 others
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MariaRD
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Jun 2024
New Mexico
Jul 24, 2025 at 3:43 AM#32
PharmHunterJen said:
Cardiac biomarkers and cardiovascular risk: my cardiologist ordered advanced cardiac labs given my family history.

Metabolic syndrome resolution on cardiovascular risk: I went from meeting 5 of 5 diagnostic criteria to meeting ZERO after 13 months of treatment.

The 5 criteria (and my journey):

  1. Waist circumference: 52" → 36" ✅ Resolved
  2. Triglycerides: 266 → 96 ✅ Resolved
  3. HDL: 36 → 58 ✅ Resolved
  4. Blood pressure: 146/92 → 119/73 ✅ Resolved
  5. Fasting glucose: 116 → 88 ✅ Resolved

Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.

Last edited: Jul 24, 2025 at 4:43 AM
33 8anders_CPH, Dr.NutriCornell, pam_stl and 30 others
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SleepDoc_PDX
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Sep 2024
Portland, OR
Jul 25, 2025 at 2:21 PM#33
PharmHunterJen said:
Cardiac biomarkers and cardiovascular risk: my cardiologist ordered advanced cardiac labs given my family history.

Lp(a) and cardiovascular risk: a nuance that matters. Unlike most lipid markers, Lp(a) is 90%+ genetically determined and doesn't really change with weight loss or GLP-1 therapy.

My Lp(a) has remained at 44 nmol/L across all time points. If yours is elevated (>50 nmol/L), you need additional risk mitigation strategies regardless of your GLP-1 response. Don't assume your medication is covering all cardiovascular risk factors.

Last edited: Jul 25, 2025 at 5:21 PM
32 7carlos_SATX, sophie_paris, mel_PDX and 29 others
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Dr.SportsMedIN
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Indianapolis, IN
Jul 27, 2025 at 12:58 AM#34

Following on from PharmHunterJen — and this may be the naive question:

Did your prescriber agree with that reading, and if not what was their objection?

Last edited: Jul 27, 2025 at 5:58 AM
31 6Dr.SurgeonPGH, rachel_ABQ, traveltech_sara and 28 others
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Dr.NateNeph
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Houston, TX
Jul 28, 2025 at 11:34 AM#35
SleepDoc_PDX said:
Lp(a) and cardiovascular risk: a nuance that matters.

Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.

Last edited: Jul 28, 2025 at 1:34 PM
30 5RickReta_CO, PharmHunterJen, TomTeleRx and 27 others
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