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ForumsCardiovascular OutcomesSTEP-HFpEF: semaglutide in heart failure with preserved EF — March 2026 Page 8

STEP-HFpEF: semaglutide in heart failure with preserved EF — March 2026

GenomicsKate Wed, Jun 4, 2025 at 7:34 PM 38 replies 1,967 viewsPage 8 of 8
MounjBrad
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Kentucky
Jan 8, 2026 at 10:41 PM#36
traveltech_sara said:
Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my…

Second this.

46 21patPC_UT, Dr.DermMIA, fiona_VT and 43 others
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tommy_boulder
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Nov 2024
Boulder, CO
Jan 21, 2026 at 12:39 AM#37
traveltech_sara said:
Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my…

Coming at traveltech_sara’s question from a different direction. The mechanism that matters here is not stomach emptying, it is central. GLP-1 receptor agonism in the arcuate nucleus stimulates POMC neurons and suppresses AgRP/NPY signalling, which is why the effect is appetite and food salience rather than physical fullness. Delayed gastric emptying largely tachyphylaxes over the first months; the appetite effect does not.

45 20TinaHashiRN, robert_kc, dan_philly and 42 others
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DataDave
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Apr 2024
Washington
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Feb 2, 2026 at 2:30 AM#38
traveltech_sara said:
Continuous metabolic monitoring dashboard for cardiovascular risk — I track everything in a spreadsheet and here's the month-over-month trend for my…

Senior perspective on cardiovascular risk: I'm 66 years old and started this journey skeptically. My internist recommended it after years of failed interventions.

8 months later: down 49 lbs, more mobile, pain reduced, medications simplified. My quality of life has improved dramatically. I wish this existed 20 years ago.

To other older adults hesitating: the SELECT trial proved benefit in our age group. You deserve to feel good in your body regardless of age.

44 19LondonLisa, mike_nyc, VendorMark and 41 others
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RunnerRach
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Aug 2024
Boston, MA
Feb 14, 2026 at 4:14 AM#39

Following on from traveltech_sara — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

43 18jennifer_SEA, tyler_CSCS, VanRx_Mike and 40 others
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SaraMom3
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Aug 2024
Ohio
Feb 26, 2026 at 5:51 AM#40
DataDave said:
Senior perspective on cardiovascular risk: I'm 66 years old and started this journey skeptically.

Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off metoprolol entirely! My cardiologist is thrilled.

If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.

21 21ZaraB_AL, JakeSmashed95, NauseaFreeNow and 18 others
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