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ForumsCardiovascular OutcomesLp(a) on GLP-1 agonists — my results so far Page 2

Lp(a) on GLP-1 agonists — my results so far

mike.trainer_LA Fri, May 16, 2025 at 9:18 AM 10 replies 1,436 viewsPage 2 of 2
Dr.ObesityLA
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May 16, 2025 at 10:23 PM#6
COA_Karl said:
Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel: Marker Baseline Month 8 Clinical Meaning LDL-P 1568 968 Particle…

Careful with treating an unchanged LDL-C as a failure. If ApoB and triglycerides both fell, the particle picture improved regardless of what the calculated LDL says.

14 17zoe_NC, Dr.ObesityLA, NurseKim_ATL and 11 others
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VendorMark
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May 17, 2025 at 3:33 AM#7
mike.trainer_LA said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Omega-3 index improvement on the lipid panel: often overlooked but my omega-3 index went from 4.0% to 7.5% over 11 months. I supplemented with 2g EPA+DHA daily.

This matters because omega-3s are anti-inflammatory and cardioprotective, complementing the GLP-1 benefits. Target omega-3 index is >8%. Combined with the triglyceride reduction from the medication, my lipid profile is the best it's been in decades.

Last edited: May 17, 2025 at 5:33 AM
15 18KristenIndy, MarkLI_maint, Dr.PeteFamMed and 12 others
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Dr.LeslieOBGYN
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May 17, 2025 at 8:42 AM#8
Dr.ObesityLA said:
Careful with treating an unchanged LDL-C as a failure.

Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:

CategoryMarkerBeforeAfter 10moChange
MetabolicA1C8.6%5.6%⬇️ 1.8%
MetabolicFasting Glucose13387⬇️ 38
LipidsLDL176105⬇️ 58
LipidsTriglycerides278123⬇️ 108
InflammationhsCRP7.51.1⬇️ 5.0

Every single metabolic marker improved. This is why I'm a believer in this therapy.

16 19james_edin, FranDenver, Dr.BariatricHTX and 13 others
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tammy_FL
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May 17, 2025 at 1:51 PM#9

One thing that is still open after Dr.PulmRoch’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

17 20Dr.PainCLE, mike_mealprep, NicoleRaleigh and 14 others
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mike.trainer_LA
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May 18, 2025 at 2:35 PM#10

Closing the loop on my own question.

Update — I was wrong in the opening post, specifically about the direction. Correcting it here rather than editing it away.

Last edited: May 18, 2025 at 6:35 PM
17 15marcus_mpls, DeniseRN_TPA, SandraNC_45 and 14 others
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