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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCardiovascular OutcomesHas anyone dealt with apob reduction on tirzepatide? Page 6

Has anyone dealt with apob reduction on tirzepatide?

tampaLisa73 Sat, Apr 26, 2025 at 11:05 AM 41 replies 2,416 viewsPage 6 of 9
Dr.PathRoch
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Jul 6, 2025 at 12:57 PM#26
BiostatsBrad said:
Say what you would expect to see if you were wrong, before you look.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

42 15MikeFit_NJ, InsuranceTom, WendyG_ATL and 39 others
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hannah_MT
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Feb 2026
Bozeman, MT
Jul 15, 2025 at 6:33 PM#27
BiostatsBrad said:
Say what you would expect to see if you were wrong, before you look.

That reframing is the part I needed. Adding it to my notes with a link back to this thread.

43 16MounjBrad, nick_newbie, DadBodDave and 40 others
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MASHdoc_SA
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Jul 25, 2025 at 12:15 AM#28

Clinical perspective, offered as context rather than as advice. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.

Worth separating that from the lipid panel, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

44 17JennaRN, LabKate, kate.chem and 41 others
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EndoResFellow
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Aug 3, 2025 at 6:02 AM#29
MASHdoc_SA said:
Start from the measurement rather than the conclusion.

Can confirm. Same sequence, different timescale. The detail I would add is minor and it is already implied above.

45 18NurseKim_ATL, paul_denver, TinaHashiRN and 42 others
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tampaLisa73
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Tampa, FL
Aug 12, 2025 at 11:54 AM#30

Reporting back.

Update — I was wrong in the opening post, specifically about the direction. Correcting it here rather than editing it away.

Last edited: Aug 12, 2025 at 12:54 PM
17 15TomFromTexas, mike.trainer_LA, sarah_nash92 and 14 others
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