Dr.PathRoch said:Semaglutide structural biology relevant to the pharmacology: semaglutide is a 31-amino acid peptide with 94% homology to native GLP-1(7-36).
Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.
From the other side of the consultation, briefly. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.
Dr.GastroMayo said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
This is where I part company with the consensus forming above. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
Correct me if the detail matters more than I have assumed.
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Browse GL BiochemOne concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.
Happy to go further on any of that.