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ForumsClinical Trials & ResearchFLOW trial: semaglutide renal outcomes — anyone have experience? Page 4

FLOW trial: semaglutide renal outcomes — anyone have experience?

steve_okc Tue, Nov 11, 2025 at 3:52 PM 23 replies 1,541 viewsPage 4 of 5
SarahChen_PharmD
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Nov 27, 2025 at 5:57 PM#16
james_edin said:
The FLOW trial results on renal function and renal outcomes: semaglutide 1.0mg reduced the composite kidney outcome by 24% (HR 0.76, p=0.0003) in CKD…

Mine went the same way, slower. The detail I would add is minor and it is already implied above.

21 19Dr.ObesityLA, NurseKim_ATL, paul_denver and 18 others
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tampaLisa73
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Nov 30, 2025 at 9:07 AM#17
DoseLogDan said:
Kidney function labs on renal function — good news for anyone concerned about renal effects: Marker Baseline Month 6 Ref Range eGFR 87 94 >60…

This matches mine closely enough to be worth saying so out loud.

22 20FitDadDave, RunnerRach, TrialNerd_Beth and 19 others
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jason_sac26
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Dec 3, 2025 at 12:16 AM#18
DoseLogDan said:
Kidney function labs on renal function — good news for anyone concerned about renal effects: Marker Baseline Month 6 Ref Range eGFR 87 94 >60…

There is a second half to this that has not been said yet. Albumin binding above 99% is the whole reason weekly dosing works, and it is also why the trough matters more than the peak. People who dose late are not losing a peak, they are letting the trough fall, and the appetite effect tracks the trough.

Correct me if the detail matters more than I have assumed.

23 21stefan_berlin, Dr.EM_Chicago, pete_RVA and 20 others
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NicoleRaleigh
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Dec 5, 2025 at 3:24 PM#19

The figures, for anyone assembling their own picture. Worth knowing that the injection site changes very little. Abdomen, thigh and upper arm are bioequivalent for semaglutide, so a site change is not a plausible explanation for a bad week.

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mike_mod
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Dec 8, 2025 at 6:30 AM#20

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. No action needed from anybody.

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