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Cholesterol dropped 80 points and my doc is shook — what worked for you?

Dr.DermMIA Thu, Jan 15, 2026 at 11:28 PM 9 replies 1,043 viewsPage 1 of 2

Dr.DermMIA

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May 2024

Miami, FL

Jan 15, 2026 at 11:28 PM#1

Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been promised.

What I am after is whether an unchanged LDL-C alongside a large triglyceride fall is a good result or a bad one, because ApoB and LDL-C seem to be telling different stories.

Happy to be told the question itself is wrong.

5 0LipidDoc_ATL, BariatricNurseD, MASHdoc_SA and 2 others

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Dr.BariatricHTX

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Feb 2024

Houston, TX

Jan 16, 2026 at 12:12 AM#2

Dr.DermMIA said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data:

Category	Marker	Before	After 8mo	Change
Metabolic	A1C	7.0%	5.4%	⬇️ 1.2%
Metabolic	Fasting Glucose	115	85	⬇️ 35
Lipids	LDL	158	102	⬇️ 40
Lipids	Triglycerides	260	105	⬇️ 90
Inflammation	hsCRP	5.5	0.8	⬇️ 5.0

Every single metabolic marker improved. This is why I'm a believer in this therapy.

4 24pete_RVA, CarlaRPh_TPA, steph_laguna and 1 other

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matt_MKE

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1,345

Sep 2024

Milwaukee, WI

Jan 16, 2026 at 12:56 AM#3

Dr.BariatricHTX said:
Before/after bloodwork compilation for the lipid panel — everything in one place for those who want comprehensive data: Category Marker Before After…

Advanced lipoprotein testing on the lipid panel — going beyond standard lipid panel:

Marker	Baseline	Month 8	Clinical Meaning
LDL-P	1678	978	Particle count (more precise than LDL-C)
Small dense LDL	68%	34%	Atherogenic pattern
Remnant cholesterol	42	17	Triglyceride-rich lipoproteins
oxLDL	83	46	Oxidative stress marker

The shift from small dense to large buoyant LDL is particularly important — it represents a fundamental change in the atherogenic profile.

3 23GraceAZ_72, carl_compliance, DanielChem_CHI

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mia_MS2

New Member

Jun 2026

Ann Arbor, MI

Jan 16, 2026 at 1:40 AM#4

Dr.DermMIA said:
Triglycerides dropped by half, HDL barely moved, and my calculated LDL is almost exactly where it started, which is not the outcome I had been…

Adding a me-too, because a thread of one person's experience is not much use. Nothing to add that would improve it.

Last edited: Jan 16, 2026 at 4:40 AM

2 22steve_okc, dave_SLC

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sophie_paris

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Nov 2024

Paris, FR

Jan 16, 2026 at 5:48 AM#5

Clinical perspective, offered as context rather than as advice.

Comprehensive lipid panel update relevant to the lipid panel:

Marker	Baseline	6 Months	12 Months	Reference
Total Cholesterol	247	202	192	<200
LDL	152	132	112	<100
HDL	45	46	59	>40
Triglycerides	267	162	102	<150
LDL-P	1667	1117	917	<1000

The triglyceride drop is the most impressive. My cardiologist reduced my statin dose based on these results.

CompoundTalk

Cholesterol dropped 80 points and my doc is shook — what worked for you?

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