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ForumsCardiovascular OutcomesAnti-thrombotic properties of GLP-1 receptor activation — need advice Page 3

Anti-thrombotic properties of GLP-1 receptor activation — need advice

DadBodDave Wed, Jun 26, 2024 at 3:24 AM 18 replies 1,927 viewsPage 3 of 4
KetoKyle
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Jun 27, 2024 at 3:47 AM#11
pat_auckland said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

Thank you for spelling out the reasoning rather than just the conclusion. Taking it to my next appointment.

18 16laura_annarbor, JenMemphis, pat_auckland and 15 others
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LibrarianMeg
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Jun 27, 2024 at 9:36 PM#12

From the other side of the consultation, briefly. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

Last edited: Jun 27, 2024 at 11:36 PM
19 17PharmD_Rodriguez, julia.endo, JessicaM_2024 and 16 others
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Dr.BariatricHTX
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Jun 28, 2024 at 3:25 PM#13
Dr.ReproEndo said:
I want to add the drug interaction perspective on the pharmacology.

Pushing back on Dr.ReproEndo here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

20 18Dr.EM_Chicago, pete_RVA, CarlaRPh_TPA and 17 others
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FDA_TrackerJim
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Jun 29, 2024 at 9:14 AM#14

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

That is the short version; the long version is somebody else's post.

21 19Dr.LeslieOBGYN, MikeNYC_runner and 18 others
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Admin
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Jun 30, 2024 at 3:02 AM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Tagging this one for the weekly digest.

Last edited: Jun 30, 2024 at 7:02 AM
22 20PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 19 others
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