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ForumsRetatrutide & Triple AgonistsRetatrutide vs tirzepatide — need advice Page 3

Retatrutide vs tirzepatide — need advice

Dr.Martinez Sat, Mar 14, 2026 at 9:12 PM 33 replies 1,276 viewsPage 3 of 7
JessicaH_TX
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Mar 15, 2026 at 5:56 AM#11
anders_CPH said:
The GIP arm is doing real work rather than padding the label.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

28 1wendy_avl, jason_paloalto, Dr.LeslieOBGYN and 25 others
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jim_asheville
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Mar 15, 2026 at 10:08 AM#12
WendyG_ATL said:
The glucagon component looks paradoxical and is not.

Thank you for spelling out the reasoning rather than just the conclusion.

Last edited: Mar 15, 2026 at 1:08 PM
29 2BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 26 others
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Dr.SleepRoch
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Mar 15, 2026 at 2:20 PM#13
anders_CPH said:
The GIP arm is doing real work rather than padding the label.

I read this differently from anders_CPH, on substance rather than tone. The "tirzepatide is simply better" summary irritates me. It is better on mean weight loss, and the cardiovascular outcome evidence is far thinner than semaglutide's. If the reason for treating is cardiovascular risk rather than weight, the evidence base points the other way.

30 3Dr.NephBHM_UK, kim_atl_prep, sarah_TO and 27 others
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VendorMark
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Mar 15, 2026 at 6:32 PM#14

The figures, for anyone assembling their own picture. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

Last edited: Mar 15, 2026 at 8:32 PM
31 4Dr.PeteFamMed, claudia_zurich, nancy_portland and 28 others
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Admin
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Mar 15, 2026 at 10:44 PM#15

Moderator note: a couple of off-topic posts removed. No action needed from anybody.

32 5PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 29 others
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