🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide dual agonism: gip + glp-1 synergistic mechanism? Page 10

Has anyone dealt with tirzepatide dual agonism: gip + glp-1 synergistic mechanism?

robert_kc Fri, Apr 5, 2024 at 12:28 AM 49 replies 2,765 viewsPage 10 of 10
LindaRN_retired
Member
189
890
Dec 2024
Sarasota, FL
Feb 12, 2025 at 3:30 AM#46
PharmHunterJen said:
The version of this that has an answer is narrower than the version being asked.

Adding the part of the answer the thread has not reached. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Correct me if the detail matters more than I have assumed.

Last edited: Feb 12, 2025 at 6:30 AM
4 2DataDave, Dr.GutHealth, amsterdam_pete and 1 other
Reply Quote Save Share Report
robert_kc
Member
289
1,234
Oct 2024
Kansas City, MO
Feb 23, 2025 at 6:50 AM#47

Closing the loop on my own question.

Reporting back after another eight months at the same dose. Still losing slowly, no new side effects, and no reason I can find to climb further.

Last edited: Feb 23, 2025 at 8:50 AM
5 3SleepFixSam, PurityPaulOR, MaxMetOK and 2 others
Reply Quote Save Share Report
SleepFixSam
Member
212
678
Nov 2024
Hawaii
Mar 6, 2025 at 10:03 AM#48

One thing that is still open after PharmHunterJen’s answer:

Did your prescriber agree with that reading, and if not what was their objection?

6 4raj_cambridge, ingrid_STO, pete_nash and 3 others
Reply Quote Save Share Report

PeptideMeter — Independent Peptide Analytics

Community-driven peptide testing and vendor rating platform. Transparent results. Unbiased analysis. Trusted by thousands.

View Results
MeganSA_TX
Member
634
2,890
Jun 2024
San Antonio, TX
Mar 17, 2025 at 1:10 PM#49

Old thread, but it comes up first when you search for this, so it is worth updating. Worth stating the units and the reference range whenever you post a number here. A large fraction of the apparent disagreement in these threads is two people using different units and both being right.

7 5TomFromTexas, mike.trainer_LA, sarah_nash92 and 4 others
Reply Quote Save Share Report
ChrisMacros
Member
567
2,345
Sep 2024
Michigan
Mar 28, 2025 at 4:10 PM#50
robert_kc said:
Reporting back after another eight months at the same dose.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

Worth separating that from the pharmacology, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

29 2bri_stats, pete_manc_UK, anna.melb_AU and 26 others
Reply Quote Save Share Report

Similar Threads

SURMOUNT-5: Tirzepatide vs semaglutide head-to-head — full results11 replies
SURPASS 1-5 program: tirzepatide T2DM efficacy data compilation6 replies
Tirzepatide dual agonism: GIP + GLP-1 synergistic mechanism18 replies
5mg → 10mg → 15mg titration — clinical guidance and real-world data8 replies
Zepbound insurance coverage — payer-by-payer breakdown 20268 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register