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ForumsTirzepatide (Mounjaro / Zepbound)Has anyone dealt with tirzepatide dual agonism: gip + glp-1 synergistic mechanism? Page 4

Has anyone dealt with tirzepatide dual agonism: gip + glp-1 synergistic mechanism?

robert_kc Fri, Apr 5, 2024 at 12:28 AM 49 replies 2,765 viewsPage 4 of 10
Dr.RenalNash
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Apr 22, 2024 at 10:06 PM#16

Clinical perspective, offered as context rather than as advice. It helps to ask what evidence would change your mind before you look at any. If nothing would, the discussion is not about evidence, and it is better to say so early than to spend nine posts discovering it.

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Dr.LipidDallas
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Apr 25, 2024 at 10:50 AM#17
Dr.RenalNash said:
It helps to ask what evidence would change your mind before you look at any.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

Last edited: Apr 25, 2024 at 12:50 PM
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Dr.EndoIndy
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Apr 27, 2024 at 11:33 PM#18
Dr.RenalNash said:
It helps to ask what evidence would change your mind before you look at any.

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

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FranDenver
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Apr 30, 2024 at 12:14 PM#19
Dr.RenalNash said:
It helps to ask what evidence would change your mind before you look at any.

Thank you for spelling out the reasoning rather than just the conclusion. I will report back once I have actually tried it.

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Admin
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May 3, 2024 at 12:54 AM#20

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.

Last edited: May 3, 2024 at 4:54 AM
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