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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersLipid panel improvements mega-thread — November 2025

Lipid panel improvements mega-thread — November 2025

MikeFit_NJ Tue, Dec 2, 2025 at 1:28 AM 10 replies 1,176 viewsPage 1 of 2
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MikeFit_NJ
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Dec 2, 2025 at 1:28 AM#1

My prescriber ordered three tests and this board recommends about twenty, and I would like to know which of those two lists is right.

What I am after is what actually belongs on a baseline panel, as opposed to the enormous list that gets pasted around here.

I have searched first, so if this is covered somewhere point me at it and I will read it.

5 0LeilaHI, marcus_mpls, DeniseRN_TPA and 2 others
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RetaRick_CA
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Dec 2, 2025 at 2:00 AM#2

Short answer first, then the reasoning. Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c becomes informative again, since it reflects about three months of glycaemia. After the first year, and once doses are stable, annual is reasonable unless something specific is being followed.

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JenPlateau
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Dec 2, 2025 at 2:32 AM#3
RetaRick_CA said:
Quarterly for the first year is convention rather than evidence, and it is defensible for a simple reason: it is roughly the interval over which HbA1c…

Agreed, and reference ranges are laboratory-specific. Comparing your number to somebody else's range, or to a screenshot from another country, is how people convince themselves something is wrong.

I would rather be corrected than agreed with, if it comes to it.

Last edited: Dec 2, 2025 at 8:32 AM
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DeniseRN_TPA
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Dec 2, 2025 at 3:04 AM#4
MikeFit_NJ said:
My prescriber ordered three tests and this board recommends about twenty, and I would like to know which of those two lists is right.

This matches mine closely enough to be worth saying so. A defensible baseline is short: HbA1c and fasting glucose, a lipid panel with ApoB if you can get it, ALT and AST, creatinine with eGFR, TSH, ferritin and B12, and a full blood count. That set catches the things that change, the things that explain symptoms, and the things that alter the prescribing decision. Almost everything else on the long circulating lists is either invariant, uninterpretable without a specific question, or an incidental finding waiting to cause an unnecessary workup.

2 22LindaRN_retired, tommy_boulder
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KevinCompounds
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Dec 2, 2025 at 5:58 AM#5

Adding the clinical framing, because it changes how the question reads.

PSA: get baseline labs BEFORE starting baseline bloodwork therapy. You need a "before" picture to measure progress. My recommended pre-treatment panel:

  1. CMP + A1C + fasting insulin
  2. Complete lipid panel with particle count if possible
  3. hsCRP, ferritin, B12, vitamin D
  4. Thyroid panel (TSH + free T4)
  5. CBC with differential
  6. Liver panel (ALT, AST, GGT)
  7. DEXA scan or body composition

Total cost at Quest without insurance: ~$200. Worth every penny for the data.

1 21NurseAsh_DET
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