From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Reporting back.
Reporting back with a partial result, because a partial result is still better than silence. Two of the three things suggested helped; I cannot separate them and I am not going to pretend otherwise.
GenomicsKate said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Coming at GenomicsKate’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
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Browse GL BiochemThe figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.
Ask again with the specifics and you will get a better answer than this one.
A narrower follow-up, since the general answer is now clear:
How would you tell the difference between that and the alternative explanation?