Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
So the question, as narrowly as I can put it: how much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical.
I have searched first, so if this is covered somewhere point me at it and I will read it.
FranDenver said:Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
6 month update on cardiovascular risk: down 52 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
Dr.NutriCornell said:6 month update on cardiovascular risk: down 52 lbs, off blood pressure meds, A1C normalized.
Positive "side effect" of cardiovascular risk: my blood pressure dropped so much that I'm now off losartan entirely! My cardiologist is thrilled.
If you're on BP meds and losing weight on a GLP-1, monitor your BP at home regularly. Hypotension symptoms (dizziness, lightheadedness when standing) mean your BP meds may need reduction. Don't wait for your next scheduled appointment — call your doctor.
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Browse GL BiochemFranDenver said:Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
Adding a me-too, because a thread of one person's experience is not much use. I had assumed I was the exception until I read this.
Adding the clinical framing, because it changes how the question reads.
Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 → elevated homocysteine → increased cardiovascular risk marker.
The connection: B12 is a cofactor for homocysteine metabolism. Without adequate B12, homocysteine accumulates. This is ironic — taking a CV-protective medication while developing a CV risk factor from reduced nutrition.
Solution: comprehensive vitamin supplementation and regular lab monitoring. Don't let the medication's benefits be undermined by nutritional deficiencies.