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Evidence-based GLP-1 & peptide discussion since 2023
ForumsLab Results & BiomarkersSHBG changes during weight loss on GLP-1 — my results so far Page 7

SHBG changes during weight loss on GLP-1 — my results so far

tampaLisa73 Thu, Sep 18, 2025 at 7:38 AM 45 replies 1,803 viewsPage 7 of 9
DataDave
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Jan 3, 2026 at 7:55 AM#31
Dr.GutHealth said:
Practical: whatever you change, write down the date and the reason.

Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.

17 15VendorMark, COA_Karl, MikeFit_NJ and 14 others
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marco_milano
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Jan 11, 2026 at 6:39 PM#32
Dr.GutHealth said:
Practical: whatever you change, write down the date and the reason.

This is exactly what I could not find anywhere else.

Last edited: Jan 11, 2026 at 10:39 PM
18 16alex_tucson, kevin_tulsa, Dr.PainCLE and 15 others
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Dr.PathRoch
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Jan 20, 2026 at 5:19 AM#33

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

19 17WendyG_ATL, SaraMom3, Dr.MetabolicMD and 16 others
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denise_HTX
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Jan 28, 2026 at 3:54 PM#34
Dr.PathRoch said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Can confirm. Same sequence, different timescale. Posting only so the count is not one.

20 18KevinCompounds, TirzTom, TrialTracker_MD and 17 others
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Dr.ReproEndo
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Feb 6, 2026 at 2:24 AM#35
Dr.PathRoch said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

There is a second half to this that has not been said yet. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

21 19carl_compliance, DanielChem_CHI, marco_milano and 18 others
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