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ForumsRetatrutide & Triple AgonistsTriple agonist side effect profile — what worked for you? Page 2

Triple agonist side effect profile — what worked for you?

Dr.BariatricHTX Tue, Nov 25, 2025 at 6:51 PM 12 replies 1,209 viewsPage 2 of 3
mike_nyc
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Nov 25, 2025 at 10:48 PM#6
Dr.GastroMayo said:
The useful move here is to separate what is established from what is widely repeated.

I would rather people stopped quoting the 24% as if it were a licensed outcome. It is a phase 2 result in a few hundred participants with no cardiovascular endpoint and no long-term safety data, and this board has a habit of treating pipeline numbers as settled.

Last edited: Nov 26, 2025 at 2:48 AM
31 1maya_sedona, stefan_berlin, Dr.EM_Chicago and 28 others
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PeptideSynthNJ
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Nov 26, 2025 at 12:21 AM#7

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

30 0NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 27 others
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Dr.EndoIndy
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Nov 26, 2025 at 1:54 AM#8
mike_nyc said:
I would rather people stopped quoting the 24% as if it were a licensed outcome.

There is a second half to this that has not been said yet. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

29 24marcus_mpls, DeniseRN_TPA, SandraNC_45 and 26 others
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MariaRD
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Nov 26, 2025 at 3:27 AM#9

Following on from tommy_boulder — and this may be the naive question:

What the phase 2 dropout pattern implies about how the phase 3 tolerability will read?

28 23rick_sfbay, maria_elpaso, anders_CPH and 25 others
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Dr.BariatricHTX
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Nov 26, 2025 at 10:52 AM#10

Closing the loop on my own question.

Rereading it with the dropout table open changed my view. I still think it is the most interesting molecule in the pipeline; I no longer think the 24% is the number that will end up on a label.

10 8maya_sedona, stefan_berlin, Dr.EM_Chicago and 7 others
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