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ForumsRetatrutide & Triple AgonistsTriple agonist sounds scary - is it actually safe — looking for input Page 2

Triple agonist sounds scary - is it actually safe — looking for input

Dr.PulmRoch Mon, Oct 27, 2025 at 9:12 PM 12 replies 1,132 viewsPage 2 of 3
Dr.SurgeonPGH
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Oct 27, 2025 at 11:50 PM#6
InsuranceTom said:
It helps to ask what evidence would change your mind before you look at any.

I would rather people stopped quoting the 24% as if it were a licensed outcome. It is a phase 2 result in a few hundred participants with no cardiovascular endpoint and no long-term safety data, and this board has a habit of treating pipeline numbers as settled.

15 10DoseLogDan, SleepFixSam, PurityPaulOR and 12 others
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DoseLogDan
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Oct 28, 2025 at 12:51 AM#7

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

Last edited: Oct 28, 2025 at 1:51 AM
14 9Dr.AddMedPHL, newstart_MO, mia_MS2 and 11 others
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SleepDoc_PDX
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Oct 28, 2025 at 1:52 AM#8
Dr.SurgeonPGH said:
I would rather people stopped quoting the 24% as if it were a licensed outcome.

There is a second half to this that has not been said yet. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

13 8carlos_SATX, sophie_paris, mel_PDX and 10 others
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JenPlateau
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Oct 28, 2025 at 2:53 AM#9

A narrower follow-up, since the general answer is now clear:

What the phase 2 dropout pattern implies about how the phase 3 tolerability will read?

Last edited: Oct 28, 2025 at 8:53 AM
12 7FitDadDave, RunnerRach, TrialNerd_Beth and 9 others
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Dr.PulmRoch
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Oct 28, 2025 at 7:45 AM#10

OP back with an update, since a thread like this is useless without one.

Rereading it with the dropout table open changed my view. I still think it is the most interesting molecule in the pipeline; I no longer think the 24% is the number that will end up on a label.

Last edited: Oct 28, 2025 at 8:45 AM
6 4KristenIndy, MarkLI_maint, Dr.PeteFamMed and 3 others
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