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ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? — my results so far Page 3

Will reta make sema and tirz obsolete? — my results so far

raj_cambridge Thu, Sep 18, 2025 at 10:58 PM 45 replies 1,803 viewsPage 3 of 9
SarahChen_PharmD
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Sep 20, 2025 at 12:49 AM#11
Dr.PeteFamMed said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

40 13Dr.ObesityLA, NurseKim_ATL, paul_denver and 37 others
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sarah_TO
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Sep 20, 2025 at 9:27 PM#12
kim_atl_prep said:
The phase 2 numbers were about 24% mean weight loss at 48 weeks on the top dose, with the curve still descending at the end of the study.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.

Last edited: Sep 21, 2025 at 1:27 AM
41 14Dr.EndoEP, GraceAZ_72, carl_compliance and 38 others
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Dr.ObesityMed
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Sep 21, 2025 at 6:04 PM#13
Dr.PeteFamMed said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

42 15SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 39 others
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LabKate
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Sep 22, 2025 at 2:41 PM#14

Adding the numbers, since they settle part of this. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

Last edited: Sep 22, 2025 at 5:41 PM
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mike_mod
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Sep 23, 2025 at 11:17 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.

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