🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsRetatrutide & Triple AgonistsWill reta make sema and tirz obsolete? — my results so far Page 8

Will reta make sema and tirz obsolete? — my results so far

raj_cambridge Thu, Sep 18, 2025 at 10:58 PM 45 replies 1,803 viewsPage 8 of 9
nancy_portland
Member
345
1,567
Aug 2024
Portland, ME
Nov 18, 2025 at 5:33 AM#36
Dr.SleepRoch said:
Worth answering the question that was asked rather than the one behind it.

Adding the part of the answer the thread has not reached. It is worth asking what the claim would look like if it were false. If nothing would look different, it is not a claim about the world and no amount of discussion will settle it.

Last edited: Nov 18, 2025 at 6:33 AM
7 5DebRD_ATL, KristenIndy, MarkLI_maint and 4 others
Reply Quote Save Share Report
Dr.PathRoch
Member
456
2,123
Jun 2024
Rochester, MN
Nov 21, 2025 at 1:53 PM#37

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

8 6InsuranceTom, WendyG_ATL, SaraMom3 and 5 others
Reply Quote Save Share Report
pam_columbus
Member
312
1,345
Aug 2024
Columbus, OH
Nov 24, 2025 at 10:11 PM#38

A narrower follow-up, since the general answer is now clear:

Was that from a primary source or from a summary of one?

Last edited: Nov 25, 2025 at 4:11 AM
9 7Dr.LipidDallas, alex_tucson, kevin_tulsa and 6 others
Reply Quote Save Share Report

Janoshik Analytical — Independent Testing

Trusted third-party HPLC & mass spectrometry analysis. Verify peptide purity with the lab the community relies on. Independent. Accurate. Transparent.

Verify Your Peptides

GL Biochem (Shanghai) Ltd. — Direct Manufacturer

Est. 1998. The synthesis house behind the vials you send for testing. ISO 9001 and cGMP certified, 1,500+ staff, batch-specific COA with every order.

Browse GL Biochem
mike_mealprep
Member
412
1,890
Jul 2024
Chicago, IL
Nov 28, 2025 at 6:27 AM#39
Dr.PathRoch said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Pushing back on Dr.PathRoch here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

10 8mel_PDX, Dr.AddMedPHL, newstart_MO and 7 others
Reply Quote Save Share Report
AmyNC_wife
Member
634
2,890
Jun 2024
North Carolina
Dec 1, 2025 at 2:41 PM#40
Dr.PathRoch said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Agreeing with Dr.PathRoch, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

Last edited: Dec 1, 2025 at 3:41 PM
32 5Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 29 others
Reply Quote Save Share Report

Similar Threads

TRIUMPH-3 topline results — 24.2% body weight loss at 48 weeks10 replies
Retatrutide mechanism: GLP-1/GIP/glucagon triple agonism explained5 replies
Retatrutide Phase 2 dose-response analysis — optimal dose range10 replies
Glucagon receptor agonism and hepatic lipid oxidation — MASH implications13 replies
Retatrutide vs tirzepatide — dual vs triple agonist comparison22 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register